Custom Peptides
Cayman Chemical Alcaftadn 10mg
A H1 histamine receptor antagonist (IC50 = 8.6 nM) with anti-inflammatory and mast cell stabilizing effects; reduces edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg); has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis
Cayman Chemical DersImelagon 10mg
An MC1R agonist; selectively induces cAMP accumulation in HEK293 cells expressing human MC1R (EC50 = 8.16 nM) over HEK293 cells expressing human MC2R (EC50 = >10,000 nM) but also induces cAMP accumulation in HEK293 cells expressing human MC4R (EC50 = 79.6 nM); increases melanin levels in B16-F1 melanocytes (EC50 = 13 pM); increases eumelanin levels in the hair roots of, and induces coat darkening in, mice at 0.3 or 3 mg/kg per day; decreases bleomycin-induced increases in skin thickness, skin levels of collagen, dermal levels of myofibroblasts, lung weight, and serum levels of PSP-D, adiponectin, Mmp-2, Mmp-3, P-selectin, Tnfr1, and Tnfr2 in a mouse model of bleomycin-induced systemic sclerosis
Cayman Chemical -CloprostenolsodIum salt 10mg
(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol.
Cayman Chemical DPTA Nonate 10mg
A NO donor with a half-life of three hours at 37°C, pH 7.4; liberates two moles of NO per mole of parent compound
Cayman Chemical SGC0946trIfluoROCTAte sal 10mg
A DOT1L inhibitor (IC50 = 0.3 nM); selective for DOT1L over a panel of 12 additional protein methyltransferases, DNMT1, and a panel of 29 receptors and ion channels; reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 = 8.8 nM); selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 µM; adoptive transfer of isolated human CD3+ T cells pre-incubated with SGC0946 (0.5 µM) prevents weight loss, increases survival, and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD
Cayman Chemical 7-BIopterIn 10mg
A pterin; formed by non-enzymatic rearrangement of 4a-hydroxy-tetrahydropterin in the absence of PCD in vitro and levels are elevated in the urine of hyperphenylalaninemia patients carrying heterozygous mutations in the PCBD gene encoding PCD
Cayman Chemical Cortolone 10mg
A metabolite of cortisol; urinary levels are decreased in postmenopausal women with endometrial adenocarcinoma compared to postmenopausal women without endometrial adenocarcinoma
Cayman Chemical 4MethyLMbelIferylNacetyl 10mg
A fluorogenic substrate of neuraminidases; cleaved by neuraminidases to release the fluorescent moiety 4-MU; has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus
Cayman Chemical ProstaglndIn F2a Alcohol 10mg
PGF2α-OH is an analog of PGF2α in which the C-1 carboxyl group has been reduced to a primary alcohol. Biological studies on rat uterus show it to be a weak agonist.{7477} The compound is reported to retain ocular hypotensive properties,{7418} but the nature of the receptors which mediate these effects is disputed.{9585}
Cayman Chemical ZLRGGAMCtrIfluoroacetAT 10mg
A fluorogenic substrate for isopeptidase T; AMC is released upon enzymatic cleavage by isopeptidase T and its fluorescence can be used to quantify isopeptidase T activity; ex/em = 340-360/440-460 nm, respectively
